Panchgani is just under 100 kms from Pune and it takes around 3 hrs to reach Panchgani. First 70-80 kms is via NH4 (Mumbai - Bangalore National Highway 4) which is a toll road and then you need to make a right at Surul Village to go to Wai - Panchgani. Ample signboards are there on the road t guide you through.
Panchgani From Mumbai
To reach Panchgani you could either take the Goa Highway route or take the route via Pune.
After crossing Panchgani continue on the Panchgani Mahabaleshwar Route. Sai Palace is less than two Kms from the Panchgani Bazaar towards Mahabaleshwar and you will find the Hotel Sai Palace on the right side of the road.